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The process has the advantage that less extraction medium is required because the solubility of one solvent in water is substantially independent of the other and solvent selection is increased, especially with solvents that are particularly difficult to extract

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Potential long-term complications for the patients include duodenal ulcers, intestinal metaplasia with dysplasia, gastric adenocarcinoma (non-cardia intestinal-type), and spontaneous diffuse gastric cancer (29)