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Screening and identification of key biomarkers associated with amyotrophic lateral sclerosis and depression using bioinformatics

In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)

The glutathionylation leads to formation of products being most frequently less toxic in comparison to the parent compounds

doi: 10.1128/mbio.02717-21