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Glutathione reductase (GR) which catalyzes the reduction of GSSG using NADPH as a reductant is also a glutathione-linked enzyme involved in cell protection

However, one plausible hypothesis is that, unlike in childhood ASD, glutamatergic neurotransmission in adults with ASD might serve a compensatory function, as discussed in the preceding paragraph

For instance, studies have shown that targeted inhibition of ACSS2-mediated acetyl-CoA synthesis caused growth inhibition of cultured tumor cells and significantly reduced the growth and size of tumor xenografts in mice 67

Peer review discussions suggest potential relevance for endothelial and microvascular dysfunction