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In fact, apart from ensuring direct access through the mucin, it was this recognition (of such a low 2-3uM solubility for niclosamide at neutral pH), that went into the initial thinking (see Supplemental Information S1 ) and prompted the invention and development of a niclosamide solution as opposed to any microparticle formulation that were all explored in the series of provisional patents (48)

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High purity means the compound is what it claims to be

When B12 levels are insufficient, this protective coating can deteriorate, leading to improper nerve function and ultimately nerve damage