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In an animal-based study, no significant adverse effects were reported in dogs, who were administered up to 300 mg of glutathione per kg body weight every day for 26 weeks

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In the AKI subgroup, the mortality rate was 8.8%, while in the non-AKI subgroup, the mortality rate was 0.7% [112]

Studies may use the precautionary principle as an argument for evaluating exposure to high doses of MP and NP before assessing the environmental dose