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The compound's selectivity profile minimizes concerns about off-target effects, but investigators should consider potential interactions with other NAD+-modulating interventions or compounds that affect methylation metabolism

PMID 16953016

[10] They are used for the swelling and bloating of premenstrual syndrome, for treating high blood pressure, and in older people for heart failure caused by weakening of the heart's pumping mechanism

The TRF1 TRFH structure was solved by molecular replacement in Phaser MR 55 within CCP4 56 using the previously published TRF1 TRFH structure as a search model (PDB: 1H6O) 31 , after having first stripped the search model of solvent molecules and ligands