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Therefore, the System Xc GSHGPX4 axis constitutes a complete and finely tuned antioxidant defense chain ( via genetic knockout in various cell types, or directly targeting its active site with small molecule inhibitors like RSL3, consistently and efficiently induces typical ferroptosis (Wang L

Atrophy of the right hippocampus and temporal lobes (Serra et al., 2010), reduced cortical thickness of the left medial orbitofrontal region (Whitehead et al., 2012), and hypometabolism of the left occipital region (Serra et al., 2010)

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Cheah IK, Feng L, Tang RMY, et al