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For a detailed breakdown of route-specific mechanisms, absorption differences, and use-case matching, see GHK-Cu Topical vs Injectable: Route Comparison

doi: 10.1073/pnas.95.16.9562

When you dont produce enough to fight off those free radicals, you suffer from oxidative stress which can intensify, stimulating diabetes, rheumatoid arthritis, and even cancer

Smoking also may impair the phase II metabolites, thus creating more estrogen quinone metabolites with a decreased ability to eliminate them.[ref][ref] Therefore, the combo of variants in phase I and phase II genes (genotype report below) with smoking causes a fairly large increase in the risk of cervical, breast, or prostate cancer