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Lancet 366 , 9991004 (2005)

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cuprizone (CPZ) group, administered 0.6% CPZ for 4 weeks, sham group, administered 0.6% CPZ and dimethyl sulfoxide for the same period, and AST group, administered cuprizone CPZ daily along with administered AST at a dose of 3 mg/kg administered 12 h later for 4 weeks