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Pregnant or breastfeeding women safety unknown Cancer patients or those with tumor history due to VEGF promotion, angiogenesis could theoretically support tumor growth Autoimmune disorders while BPC-157 is generally anti-inflammatory, immune modulation can vary by individual Angiogenic peptides may pose theoretical risks in neoplastic conditions by promoting blood vessel formation

While we usually think about low B12 causing anemia, a few case reports describe new or worsened polycythemia - an elevated red cell mass - after B12 administration

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However, conventional medicine considers the majority of cases idiopathic, meaning the cause is unknown (Marangella 2008