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As a reaction to the high variability in intrapatient trough levels, which are associated with worse outcomes (124129), once-daily administered Tac formulations with prolonged drug release have been developed to improve bioavailability and adherence as well as lower intraday fluctuation and peak concentrations (Cmax), as illustrated in Figure 1

Nausea, vomiting, diarrhea, constipation, and decreased appetite have all been reported, with frequency and severity dependent on dose and titration schedule

Patients suffering from major depression had reduced levels of immunoreactive DSIP compared to control subjects, as shown in cerebrospinal fluid (CSF) analysis