IC 50 for unbound drug (IC 50,u ) values were calculated using the following equation: IC 50,u = IC 50 f u,inc

DOI: Published online: March 4, 2021 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea 2 Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Gumi Hospital, Soonchunhyang University College of Medicine, Gumi, Korea 3 Division of Endocrinology and Metabolism, Department of Internal Medicine, Korean Armed Forces Capital Hospital, Seongnam, Korea 4 Department of Family Medicine, Korea University College of Medicine, Seoul, Korea 5 Department of Biostatistics, Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea Corresponding authors: Won-Young Lee Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Korea E-mail: [email protected] Eun-Jung Rhee Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Korea E-mail: [email protected] *Se Eun Park and Mi Hae Seo contributed equally to this study as first authors

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