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In addition to the central role of TLR4, small IONPs (10-60 nm) also interact and activate other surface TLRs such as TLR2 and TLR6, as well as the intracellular TLR8 (176, 177)

Bartus RT, Dean RL 3rd, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction

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