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The compound then received GRAS (Generally Recognized as Safe) designation from the FDA for use as a food ingredient, which is a separate regulatory category from drug approval

Copper toxicity typically occurs with chronic intake above 1015mg daily over months, presenting as gastrointestinal distress, hepatic dysfunction, or zinc depletion

The synthesis constitutes a formal total synthesis, since the research groups only prepared the known intermediate cobyric acid, whose chemical conversion to vitamin B 12 was previously reported

Route reported Oral capsule/powder is by far the most commonly discussed route commercially