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First-level effects were carried out by means of general linear models, incorporating task effects and covariates of no interest (a linear trend to account for low-frequency drift and rigid-body motion parameters were included as single-subject regressors to partially account for movement effects, age, and education) were convolved with a canonical hemodynamic response function and used to compute parameter estimates ( ) and contrast images (containing weighted parameter estimates) for each cue category at each voxel

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They may swell and feel tender