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Exogenous ACTH is capable of phase-dependently resetting glucocorticoid rhythms (182), suggesting that the adrenal circadian clock can be entrained by the ACTH rhythm

Analysis of adverse effects (OR = 0.03, 95% CI: 0.030.09) revealed comparable safety profiles, with reported events primarily consisting of gastrointestinal symptoms (abdominal pain, nausea, reflux, diarrhea, constipation, flatulence, and indigestion), neurological effects (headache and daytime drowsiness), and occasional hypersensitivity reactions or cold sores

Currently, it is recommended that patients with PCOS undergo regular screenings for cardiovascular diseases and related tumors, especially those with risk factors such as central obesity, overweight, diabetes, and prediabetes

Gutmammary axis Beyond exogenous infection, endogenous mechanisms mediated by the gutmammary axis have recently gained attention