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4.2 Lack of specific biomarkers and translational limitations of therapeutics The clinical translation of ferroptosis-targeted strategies is bottlenecked by two critical barriers: the absence of specific, standardized biomarkers for ferroptosis in renal tissues and biofluids, and the suboptimal pharmacokinetic and safety profiles of current ferroptosis modulators

Two other studies showed that L-carnitine attenuates cancer cachexia through regulating the activity of CPT [24, 38]

Reactive oxygen species: impact on skeletal muscle