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Agents that cause depletion of catecholamines from the sympathetic nerve terminals (e.g., reserpine) can also antagonize indirectly acting agents (such as tyramine) because there is a lack of catecholamines to be released

We urge FDA to take quick and aggressive action to enforce the law before one or more of these products become the next Juul phenomenon among our nations youth. In April, the same six organizations urged the FDA to take action to address Juuls popularity among youth, including removing from the market Juul flavors such as mango and cool cucumber that appear to have been introduced after August 8, 2016, without FDA review