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IS also enhances the expression of cytochrome P450 family 1 subfamily A member 1 ( CYP1A1 ), cytochrome P450 family 1 subfamily B member 1 ( CYP1B1 ), and inflammatory cytokines (TNF-) in T cells through activating AHR pathway, as well as modulating inflammatory responses and cell cycle regulation ( Figure 3 ) [84]