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Many users in these forums attribute this reaction to acute mast cell activation triggered by the peptide complex, noting that they require the concurrent, daily use of potent systemic antihistamines (such as Xyzal) simply to tolerate the basic administration of the protocol

[DOI] [PubMed] [Google Scholar] [25].Ward NE, Pierce DS, Chung SE, Gravitt KR, OBrian CA

These gene expression data are available through the Gene Expression Omnibus (GEO) under the accession GSE27597

Informed consent documentation should state that the treatment is compounded, that the compound is not FDA-approved for the intended use, and that clinical evidence is limited