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Both male and female adipose-specific knockout mice displayed significantly lower body weight and fat mass in response to HFD challenge (Fig

In the phase 2 trial of cagrilintide 2.4 mg co-administered with semaglutide 2.4 mg (CagriSema) in people with type 2 diabetes, the combination improved glycemic control and body weight relative to semaglutide alone, consistent with amylin adding a postprandial glucose-lowering contribution on top of GLP-1 action

Peptides reach peak blood levels more quickly, which may be advantageous for certain research applications

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