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2024, Abouelrous et al

Acetyl coenzyme A condenses to form 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA), which is then converted to MVA by HMG-CoA reductase

It was well established that the hepatotoxicity of APAP begins with the metabolic conversion of APAP to its reactive metabolite (N/-acetyl-p-benzoquinone imine, or NAPQI) ( CYP2E1 catalyzes the oxidation of APAP to NAPQI, a highly reactive metabolite inducing severe massive hepatocellular necrosis ( CYP2E1 knockout mice showed resistance to the APAP high dose-associated hepatotoxicity, suggesting that CYP2E1 is the major cytochrome P450 enzyme participating in APAP metabolism and toxicity ( CYP2E1 in APAP toxicity, CYP enzymes, notably CYP2E1 , generate ROS and lipid peroxidation ( As CYP2E1 is the major source of NAPQI, an evaluation of the CYP2E1 expression level was done in this study

Kojic Acid: A fungal derivative, kojic acid is another effective skin lightening agent present in fairness creams, serums, and soaps