Using two-way repeated measures of ANOVA, we determined that there were significant interactions between group and time for several metabolites, including Glu (F[10, 105] = 2.1, p = 0.031), NAA (F[10, 105] = 1.99, p = 0.041), GSH (F[10,105] = 1.97, p = 0.045), NAA + NAAG (F[10, 105] = 2.11, p = 0.03), and Glx (F[10, 105] = 2.45, p = 0.011) (Table 3)
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Nonetheless, it should be used within a certain timeframe as recommended by the pharmacy (often 28 days after first puncture, per general guidelines for multi-dose vials, unless otherwise specified)
But more chronic use, or larger doses, can cause profound damage to even a healthy liver and lead to more serious problems with a liver that already has some damage or cirrhosis