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After the third decade of life, there is a progressive decline of GH secretion by approximately 15% for every decade of adult life (7)

Furthermore, studies on serum from SZ patients showed elevated levels of polyamine oxidase (the enzyme responsible for degrading PAs) (96, 97), while the activities of three enzymes involved in PA synthesisornithine aminotransferase, antizyme inhibitor 1 (AZIN1), and ornithine cyclodeaminase were found to be reduced in the prefrontal cortex of both treated and untreated patients (98), ultimately potentially leading to disrupted polyamine homeostasis

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If you are on these medications, it is often recommended to talk to your healthcare provider about supplemental CoQ10 to maintain your levels