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Cortisol mobilizes energy to support that action but also tells the nervous system, Ill take it from here. Studies on the effects of progesterone on norepinephrine can be more telling

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Graphic Abstract Similar content being viewed by others Gut-brain Axis and Addiction Despite the impact of substance use disorders on society, few treatment options are effective, underscoring the need to explore novel therapies (Volkow and Boyle 2018)