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Plasma half-life is short (tens of minutes), but tissue effects persist for several hours through a second-messenger cascade

Signs and Symptoms of GAD People with GAD may experience: Excessive worry on most days Trouble controlling anxious thoughts Feeling nervous, restless, or on edge Trouble focusing or concentrating Irritability or mood changes Muscle tension Headaches or stomach discomfort Feeling tired often Trouble falling asleep or staying asleep Feeling overwhelmed by small tasks Worrying even when there is little or no clear reason These symptoms can make simple daily activities feel stressful or exhausting

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If you don't treat your B12 deficiency, it can lead to more severe neurological problems, including: Problems walking or speaking Vision loss Numbness or tingling Muscle weakness Difficulty remembering things Depression or mood swings Treating vitamin B12 deficiency Treatment depends on the reason for your low levels of B12