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Bacterial endotoxins, he says, can do a "serious number on you"

56 It has also been reported that in fulminant hepatic failure, toxic substances released from the necrotic hepatic remnant and lack of detoxification of substances from the gut inhibit or delay liver regeneration and the recovery of hepatic function including aminotransferase production

Furthermore, chronic overproduction of TGF1 from astrocytes and microglia leads to decreased pericyte coverage, facilitating vascular remodeling and suboptimal brain perfusion [187,188,189]