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Many trials recruited younger participants outside our target demographic of 3065 years, limiting the available evidence for middle-aged and older adults

Funding This project was financed by the National Natural Science Foundation of China (grant number 31871169 to YT, 81600040 to A-PW), Innovation guidance project of Hu Nan (grant number 2018SK51606 to S-XG, 2018SK51703 to NL), the province Natural Science Foundation of Hu Nan (grant number 2020JJ8032 to YT, 2021JJ30601 to A-PW)

Clinical Cancer Research 31(3):551-560, 2025

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