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In particular, GLP-1 analogues have shown direct effects on the plasticity of the pancreatic islet in both normal glucose tolerance and throughout the whole spectrum of alterations leading to overt diabetes [7]

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Key pathological processes common to both include chronic neuroinflammation, oxidative stress, mitochondrial dysfunction, and, in some studies, suggestive evidence of aberrant protein aggregation, and disruptions in the delicate balance between excitatory and inhibitory neurotransmission (Shulman et al., 2021

Then, of course, there was my grandmother