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Astroglial pathophysiology is complex, with different pathophysiological cell states and cell phenotypes that are context-specific and vary with disorder, disorder-stage, comorbidities, age, and sex

It is likely for such treatment including IVIG and corticosteroids that the time window to initiation to achieve a beneficial effect is very short to be feasible in clinical practice

In this study, they found that miR-378 bound to IGF-1R 3UTR directly and miR-378 overexpression enhanced apoptosis of cardiomyocytes with decreased IGF-1 signaling activity suggesting that miR-378 has a role in postnatal cardiac remodeling and cardiomyocyte survival against stressors by negatively regulating IGF-1R

doi: 10.29063/ajrh2017/v21i4.4 83 NegaS