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Rather than activating the c-Met receptor directly, Dihexa acts as an allosteric potentiator of hepatocyte growth factor (HGF), the endogenous ligand for c-Met

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Studies including healthy individuals were not eligible unless they were incorporated as a comparator or control group alongside participants with PD

Glial alterations have been reported in the subgenual ACC, dorsolateral PFC, orbitofrontal cortex, and the amygdala of unmedicated bipolar patients (157, 158)