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When an unblinded clinician rates a self-limiting condition in a cohort that has already lost a quarter of its patients, a near-universal response rate is close to the expected result whether or not the drug does anything

Kamboj AK, Dilmaghani S, Goyall R, Codipilly DC, Leggett CL, Kahn A, Probst A, Messman H, Hooda Z, Hofstetter WL , Tankel J, Ferri L, Otaki F, van de Ven S, Maan A, Koch AD, Box V, Pouw RE, Iyer PG

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They found 496 deaths in the AS cohort and 1533 deaths in the controls resulting in an age-adjusted and sex-adjusted HR of 1.60 (95% CI 1.44 -1.77)