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To mitigate any potential negative effects on methylation, additional interventions can support the methyl cycle while using folinic acid therapy: Improving SAH (S-adenosylhomocysteine) levels by reducing homocysteine through methyl donors like betaine (TMG), vitamin B6 (P5P), and methylcobalamin (B12)

In contrast, regenerative medicine offers a more proactive approach, using therapies like platelet-rich plasma (PRP), stem cells, and peptides to repair damaged tissues and promote lasting recovery without the side effects

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REDEFINE 2 (overweight/obesity with T2D) showed a 15.7% mean weight reduction and 73.5% achieving HbA1c 6.5%