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Larger needles cause more tissue displacement and tend to produce more discomfort

Clinical Update 12/14/2017 Danger from Too Much Vitamin B6 A women who was consuming large amounts of an energy drink as well as a B-vitamin complex developed symptoms of vitamin B6 (pyridoxine) toxicity (which may not be reversible), according to a recent report

Although raised homocysteine levels might be partly due to a poor vitamin B 12 status, the latter was not related to risk of dementia or Alzheimer's disease in this study (73)