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Similarly, in bipolar disorder, particularly during depressive episodes, patients exhibit altered energy metabolism marked by increased lactate levels and decreased glucose and glycine levels, which parallels results in ME/CFS that suggest TCA impairment and energy metabolism dysregulation (Yamano et al., 2016

Perhaps concentrations of the molecules from which GSH is derived might reveal group differences in this oxidative stress defense system

Why: Isotretinoin is derived from vitamin A and combining the two increases the risk of hypervitaminosis A , which can cause: Headaches / pseudotumour cerebri Liver toxicity Nausea Bone pain Skin peeling Mood changes Avoid: Vitamin A capsules Multivitamins containing high-dose retinol Cod liver oil (contains vitamin A) Most multivitamins have Vitamin A with very low levels ( 5,000 mcg

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