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Peus D, Vasa RA, Beyerle A, Meves A, Krautmacher C, Pittelkow MR

These healthspan improvement findings have profound implications for longevity research, development of geroprotective therapies, and understanding how senescent cell accumulation contributes to the functional decline characteristic of biological aging

These data raise the possibility that sudden or sustained increases in serum osmolality (e.g., in the sick premature infant administered hypertonic glucose or sodium bicarbonate, in association with hypothalamic disturbance after asphyxia or intraventricular hemorrhage, or following an exchange transfusion) could lead to abrupt increases in brain bilirubin levels even in the absence of marked hyperbilirubinemia

All three symptoms improve with adequate water intake