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and, most importantly, we see the same senitization to 5FU with other CI inhibitors, such as IACS-010759, phenformin and carboxyamidotriazole, as we do with metformin

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However, iron accumulation still occurs in AT in obese patients, which indicates that IL-6 and IL-1 in AT may cause induce damage to MFe hi and Mox, resulting in high levels of oxidative stress and lipid peroxidation of AT ( Figure 3 )