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It also induces vasorelaxation through both endothelium-dependent (activation of the NO/cGMP pathway) and independent mechanisms (inhibition of Ca 2+ influx into VSMCs, likely through the blocking of voltage-gated CCs (VGCCs)) (310)

More serious but uncommon side effects are typically linked to high or frequent dosing

In the foundational 2017 Cell study, naturally aged mice and chemotherapy-treated mice received FOXO4-DRI at 5 mg/kg by intraperitoneal (IP) injection , given on an intermittent schedule (about three times per week) across several weeks

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