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Pyroptosis is distinct from apoptotic cell death, instead representing a form of highly inflammatory necrotic cell death wherein the plasma membrane ruptures and inflammatory factors such as interleukin (IL)-1 and IL-18 are release along with other components from the cytoplasm [6]

Some young people who have tried an e-cigarette have never smoked tobacco, so vaping can be a starting point for nicotine use [19]

+ At a convenience store or gas station in Ontario, a carton of 200 cigarettes costs between $130 and $180 in 2026

Cons: Often contain high nicotine concentrations, which may exceed cigarette equivalence if overused