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The clinical significance of HPL was initially attributed to polyphenols, including naphthodianthrones (0.060.4%, hypericin, pseudohypericin, etc.), flavonoids (24%, hyperoside, quercitrin, rutin, etc.), and phloroglucinols (0.24%, hyperforin, adhyperforin, etc.) (Kennedy and Wightman, 2011)

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