As we age, NAD+ levels naturally decline, which can contribute to feelings of fatigue and a diminished sense of vitality
Ascorbic acid (vitamin C) protected folates, naturally present in foods or folic acid and 5-methyl-THF added as fortificants, against degradation by heat, oxidation, and ultraviolet radiation during processing and storage in model systems and food products
In some embodiments, the otoprotectant is any one of the following compounds: In some embodiments, the otoprotectant is a compound comprising a thiophene-carboxamide moiety core structure of Formula (I): In some embodiments, the otoprotectant is a compound comprising a thiophene-carboxamide moiety core structure of Formula (II): wherein ring A is optionally attached and is a 5-7 membered ring that is aromatic or non-aromatic and can contain one more heteroatoms (N, O, or S atoms)
This includes nicotinamide riboside kinases, nicotinamide phosphoribosyltransferase, and other methyltransferases that could confound experimental results