Common next steps may include: Further investigation with an OGTT or fasting plasma glucose test where clinically indicated Assessment for PCOS , metabolic syndrome, or metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD), including cardiometabolic risk stratification If insulinoma or another cause of endogenous hyperinsulinism is suspected, endocrinology referral is essential
It may be implicated in the hepatic fibrosis of systemic sclerosis as an anti-inflammatory cytokine by activating IL-13R1/Tyk2/Stat1/Stat6 signaling pathways in macrophages and fibroblasts [55, 60]
Scientific Activity A single direct molecular target has not been conclusively established
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