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doi:10.1016/s0006-3223(97)00277-1

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The underlying driver is chronic inflammationspecifically, dysregulated immune signaling involving TNF-, interleukins (IL-17, IL-23), and NF-B pathways

When it is time to retire, planning for the end of HSA eligibility while factoring in the 6-month rule for Medicare Part A coverage can help avoid an inadvertent excess HSA contribution (and the headaches that come with withdrawing excess contributions and potential penalty taxes)