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In previous studies, the connection between effort-based motivated performance in humans and levels of various metabolites in the accumbal region, was measured using 1 H-MRS at 7 Tesla before performing a physical effort-based motivated task (MIFT) (16, 17)

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For the identification of druggable targets, we considered three classes of enzymes: tier-1 targets, tier-2 targets, and other enzymes. Tier-1 targets correspond to enzymes whose knockout impedes viral replication while having a minimal impact on the simulated cellular viability