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Description

Anti-angiogenic drugs (VEGF pathway inhibitors and TKI) Mechanisms and clinical manifestations The premise of this type of targeted drugs is that tumor growth is highly dependent on local pathological angiogenesis induced by vascular endothelial growth factor (VEGF), which promotes tumor development by regulating vascular permeability, endothelial cell migration, proliferation, and survival (44)

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The incorporation of niacinamide into the transfersomes was accompanied by enhanced skin permeation and improved depigmenting efficacy in comparison to the conventional liposomal niacinamide formulation (Lee et al., 2016b)

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