Ginkgolide B protects against cognitive impairment in senescence-accelerated P8 mice by mitigating oxidative stress, inflammation and ferroptosis
Polyphenolic Toxicity Despite the above-documented beneficial effects of polyphenols in UTI treatment, these molecules could also exert some toxicological effects in in vitro and in vivo models
Its pathogenesis involves tumor-like proliferation of synovial fibroblasts (FLS), local infiltration of immune cells, and the release of inflammatory cytokines that exacerbate joint inflammation and bone destruction ( Ferroptosis is a mode of iron-dependent cell death that is morphologically and biochemically distinct from apoptosis, necrosis, and pyroptosis ( The endoplasmic reticulum (ER), an important organelle in eukaryotic cells, is involved in protein synthesis, folding, structural maturation, lipid metabolism, and Ca 2+ regulation
In vitro and preclinical studies indicate that cagrilintide retains high potency across amylin and calcitonin receptor subtypes and demonstrates additive pharmacodynamic effects when combined with GLP-1 agonists like semaglutide (DAscanio et al
