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Vitamin supplementation was given to most patients in the trial and pemetrexed related side effects were significantly less in patients receiving pemetrexed when they also received daily oral folate 500mcg and intramuscular vitamin B 12 1000mcg every 9 weeks compared with patients receiving pemetrexed without vitamin supplementation

They reunited for the first time since announcing their split, joining their children at the Beverly Hills Hotel last month

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