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Nanotechnology in cancer therapy The application of nanotechnology in cancer therapy includes FDA-approved drugs (Table 1) and investigational agents (Table 2)

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Although evidence substantiates impairment of both volitional and automatic prefrontallimbic circuitry, the volitional ventrolateral PFC-mediated network seems to be more compromised in bipolar than unipolar depression, possibly reflecting compromised prefrontal regulation of the subcortical limbic areas, manifested as more prominent emotional lability and reactivity in this disease state