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Camptothecin regulates microglia polarization and exerts neuroprotective effects via activating AKT/Nrf2/HO-1 and inhibiting NF-B pathways in vivo and in vitro

Mahn A, Castillo A

specifically, the end-product, GSH, accumulates in the cell and acts as an inhibitor of -glutamylcysteine ligase activity, thereby preventing the overproduction of GSH 41 (Figure 2)

Due to its strong antioxidant properties and additional anti-melanogenic effects, glutathione has gained fame as a systemic skin-lightening molecule. Glutathione is widely available in various forms, including tablets, capsules, topical preparations, and parenteral preparations