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Abstract Osteoarthritis (OA) is a progressive, whole-joint disorder driven by a convergence of biomechanical stress, inflammation, metabolic dysfunction, and cellular senescence

Furthermore, specific ileal taxa, notably Paraclostridium , actively participate in bile acids (BAs) metabolism via the secretion of bile salt hydrolase (BSH)

There is evidence that low DHEA levels are linked to the beginning and progression of metabolic syndrome and diabetes mellitus, as well as a decrease in bone mineral density (88, 89)

Cognitive functions include memory, learning, reasoning, problem-solving, verbal fluency, and visual-spatial abilities